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calculus bovis
- Development stage
- Unknown
- Lead developer
- Changhai Hospital
- Administration
- Oral
01
Overview
Calculus bovis, also known as bovine bezoar or ox gallstone, is a traditional Chinese medicine (TCM) derived from the gallstones of cattle (*Bos taurus domesticus*). Due to the rarity of natural bezoars, "Bovis cultured in vitro" (in vitro cultured bovine bezoar) is produced using biotechnological methods to ensure a consistent supply of active components, including bilirubin, cholic acid, deoxycholic acid, and taurine. In the context of oncology, it is being investigated for its ability to mitigate post-embolization syndrome (PES) in patients undergoing transarterial chemoembolization (TACE) for unresectable hepatocellular carcinoma. Its therapeutic effects are attributed to anti-inflammatory, antioxidant, and hepatoprotective properties, which help reduce liver injury markers and systemic inflammation following TACE.
- Other names
- bovine bezoarox gallstoneNiu Huangin vitro cultured bovine bezoarBovis cultured in vitroCalculus Bovis Artifactus
02
Targets
FXR (Farnesoid x-activated receptor)IL-6 (Interleukin 6)GPBAR1TNFA (Tumor necrosis factor alpha (soluble))
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