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Caldaret
- Development stage
- Phase 2
- Lead developer
- Mitsubishi Tanabe
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Caldaret is a small molecule investigational drug that acts as an intracardiac calcium (Ca2+) handling modulator. Its presumed cardioprotective mechanism involves inhibition of the sodium/calcium exchanger 1 (NCX1), particularly the reverse-mode Na+/Ca2+ exchange, and enhancement of Ca2+ uptake via the sarcoplasmic reticulum. Caldaret was developed for potential use in cardiovascular diseases, especially to limit infarct size and protect cardiac tissue during ischemia-reperfusion injury such as acute myocardial infarction. Despite promising preclinical results, Caldaret failed to demonstrate efficacy in Phase II clinical trials as an adjunct to standard therapy with primary percutaneous coronary intervention in patients with acute myocardial infarction[1][2][7].
- Other names
- caldaret hydratecaldaret monohydrate
02
Targets
NCX1 (Sodium/calcium exchanger 1)
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