calenduloside e

Calenduloside E is a natural pentacyclic triterpenoid saponin primarily isolated from the root bark of *Aralia elata* (Miq.) Seem. It is characterized by its anti-atherosclerotic and vasoprotective properties, specifically demonstrating the ability to protect human umbilical vein endothelial cells (HUVECs) from injury induced by oxidized low-density lipoprotein (ox-LDL). Its primary mechanism of action involves binding to the Heat shock protein 90 beta (HSP90β) isoform, specifically interacting with the Asp93 residue in the protein's regulatory pocket. Although it shows potential as a therapeutic lead for cardiovascular diseases, its clinical application has been hampered by relatively weak potency and a narrow therapeutic index, leading researchers to develop synthetic derivatives (such as hybridization with ticagrelor fragments) to enhance its binding affinity and efficacy.

Other names

Oleanolic acid 3-O-beta-D-glucuronide3-O-beta-D-glucuronopyranosyloleanolic acidOleanolic acid 3-glucuronide