callistemon macropunctatus fruit extract

Callistemon macropunctatus fruit extract is a research-stage natural product derived from the fruit of the scarlet bottlebrush plant (*Callistemon macropunctatus*). It is primarily investigated for its cytotoxic and anti-proliferative properties against breast cancer (MCF-7) and colon cancer (Caco-2) cell lines. The extract is a complex mixture containing flavonoids, lignans, and meroterpenes, including compounds such as avicularin, nilocitin, and quercetin derivatives. Its mechanism of action involves the induction of apoptosis and cell cycle arrest (specifically in the S-phase for breast cancer cells and G0/G1 and S-phases for colon cancer cells). Molecular docking studies suggest that the extract's components target Cyclin-dependent kinase 6 (CDK6), a key regulator of the cell cycle. Currently, it remains in the early academic research phase with no commercial pharmaceutical development identified.

Other names

Callistemon macropunctatus fruit ethanol extractscarlet bottlebrush fruit extract