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Calmatrol is a **non-specific brand name** that refers to at least two distinct marketed products rather than one uniquely identifiable drug. One Calmatrol product is a veterinary over-the-counter oral medication distributed by Goldman Pharmaceutical Group whose active pharmaceutical ingredient is **diphenhydramine**, an H1 histamine receptor antagonist used in dogs for relief of occasional restlessness, hyperactivity, destructive behavior, and anxiety associated with noise, environmental changes, loneliness, and stress. A separate Calmatrol product marketed by Ortho Molecular Products is a **multi-ingredient dietary supplement** for human use containing herbal ingredients including **valerian root**, promoted for sleep and anxiety support. Because these are different formulations, indications, species, and regulatory categories, the exact identity of \"Calmatrol\" cannot be resolved to a single drug record without choosing one of these products specifically.
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