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calpain inhibitor IV
- Development stage
- Unknown
- Lead developer
- Calbiochem
- Modality
- Small Molecules
01
Overview
Calpain inhibitor IV is a synthetic small molecule peptidomimetic compound that acts as an experimental inhibitor of calpains, which are calcium-dependent cysteine proteases. It is also known by the code name CBZ-LEU-LEU-TYR-CH2F. Calpains play roles in various cellular processes including cytoskeletal remodeling and signal transduction; their dysregulation has been implicated in neurodegenerative diseases and other pathological conditions. Calpain inhibitor IV has been used primarily as a research tool to study calpain function and inhibition, but it has not advanced to clinical development or approval for any indication[1][2][4].
- Other names
- N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamideN-[(benzyloxy)carbonyl]leucyl-N(1)-[3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]leucinamide
02
Targets
CAPN (Schistosoma calpain large subunit family)
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