Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
calpeptin
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Intraparenchymal, In Vitro
01
Overview
Calpeptin is a potent, cell-permeable inhibitor of calpains, specifically targeting calpain 1 (μ-calpain) and calpain 2 (m-calpain). While primarily characterized as a cysteine protease inhibitor, it is widely utilized in cell biology research as an indirect activator of the RhoA/ROCK signaling pathway. This activation occurs because calpeptin inhibits the calpain-mediated cleavage of proteins that regulate RhoA, thereby promoting RhoA activity and its downstream effector, Rho-associated protein kinase (ROCK). Research has demonstrated that calpeptin-induced ROCK activity can regulate the Hippo signaling pathway by increasing the nuclear localization of Yap and the expression of Yap-regulated genes. It has been investigated in preclinical models for its role in mitigating radiation-induced salivary gland dysfunction (hyposalivation) and other conditions involving cytoskeletal remodeling and cellular polarity.
- Other names
- Benzyloxycarbonyl-L-leucyl-L-norleucinalCbz-Leu-nLe-CHO
02
Targets
CAPN (Schistosoma calpain large subunit family)CTSL (Cathepsin L)Mpro (3C-like proteinase of SARS-CoV-2)ROCK1 (Rho-associated coiled-coil containing protein kinase 1)
Beyond the preview
Go deeper on calpeptin.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on calpeptin.