calystegine B2

Calystegine B2 is a naturally occurring polyhydroxy nortropane alkaloid belonging to the class of tropane alkaloids. It is found in various plants and foods such as eggplants and potatoes and has been studied for its biological activities as a glycosidase inhibitor—specifically inhibiting enzymes like alpha-galactosidase and beta-glucosidase[7][5]. This inhibition suggests potential utility in research related to lysosomal storage disorders such as Fabry disease (alpha-galactosidase deficiency) and possibly neurodegenerative diseases including Alzheimer's and Parkinson's disease[7][1]. Its mechanism of action involves competitive inhibition of glycoside hydrolases by mimicking carbohydrate substrates due to its polyhydroxylated structure.

Other names

(1R,2S,3R,4S,5R)-8-azabicyclo[3.2.1]octane-1,2,3,4-tetrol1,2,3,4-tetrahydroxy-nor-tropaneNortropanolineCalystegine B(2)Calystegin B28-Azabicyclo[3.2.1]octane-1,2,3,4-tetrol