camalexin

Camalexin is a sulfur-containing phytoalexin primarily synthesized by the plant *Arabidopsis thaliana* and other members of the Brassicaceae family in response to environmental stress or pathogen infection. Chemically identified as 3-thiazol-2-yl-indole, it has gained interest in oncology research for its potential anti-proliferative and anti-metastatic properties. In prostate cancer models, camalexin has been shown to inhibit cell growth and reverse the epithelial-mesenchymal transition (EMT) process by modulating markers such as E-cadherin and vimentin. While it demonstrates synergistic effects when combined with chemotherapeutic agents like estramustine, it remains primarily a research-stage phytochemical and is not currently an approved therapeutic.

Other names

3-thiazol-2-yl-indole