cambinol

Cambinol is a synthetic small molecule that functions primarily as an inhibitor of sirtuin proteins SIRT1 and SIRT2, which are NAD-dependent deacetylases involved in epigenetic regulation and cellular stress responses. It also acts as a potent uncompetitive inhibitor of neutral sphingomyelinase 2 (nSMase2), an enzyme implicated in ceramide production and neurodegeneration. Cambinol increases acetylation of key proteins such as p53, Ku70, Foxo3a, tubulin, and BCL6 by inhibiting sirtuin activity. This leads to cell cycle arrest, inhibition of cell growth, induction of apoptosis in cancer cells (notably B-cell lymphoma), suppression of pro-inflammatory cytokine expression (e.g., TNFα, IL‑1β), and modulation of sphingolipid metabolism. Preclinical studies suggest potential utility for cancer therapy—especially for sensitizing tumor cells to chemotherapeutic agents—and possible applications in neurodegenerative diseases due to its effects on nSMase2[1][3][4][5].

Other names

4(1H)-Pyrimidinone, 2,3-dihydro-5-((2-hydroxy-1-naphthalenyl)methyl)-6-phenyl-2-thioxo-5-(2-hydroxynaphthalen-1-yl)methyl)-6-phenyl-2-sulfanylidene-tetrahydropyrimidinonebeta-naphtol derivative