Drug intelligence / Profile preview

campesterol

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Campesterol is a phytosterol, a plant-derived sterol structurally similar to cholesterol, found naturally in many foods including vegetable oils, nuts, and seeds. It lowers LDL cholesterol by inhibiting intestinal absorption of dietary cholesterol and exhibits anticarcinogenic properties, notably inducing apoptotic cell death in cancer cell models (e.g., ovarian, liver, and lung cancer) via mitochondrial pathways involving ROS production and caspase activation[1][6]. It also possesses anti-inflammatory effects and has been investigated for support in conditions like osteoarthritis and certain prostate disorders[6]. Campesterol is a precursor in the biosynthesis of steroid hormones and may be used as a dietary supplement to help manage cholesterol levels[5][7].

Other names
campesterin24(R)-methylcholesterol(24R)-ergost-5-en-3β-olC01789C-01789C 01789ERGOST-5-EN-3-OLERGOST5-EN-3-OLERGOST 5-EN-3-OL24α-methyl cholesterolergost-5-en-3-ol, (3beta,24R)-24-methylcholesterol22,23-dihydrobrassicasterol24 alpha-methylcholest-5-en-3 beta-olcampesterol, (3beta)-isomercampesterol, (3beta,24xi)-isomerergost-5-en-3 beta- ol, 24 epimercanola sterol
02

Targets

NPC1L1 (Niemann-pick C1-Like 1 transporter)

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