Drug intelligence / Profile preview

camphor leaf oil

Development stage
Unknown
Modality
Small Molecules
Administration
Topical, Inhalation
01

Overview

Camphor leaf oil is a plant-derived essential oil obtained from the leaves of Cinnamomum camphora. It contains the active compound camphor, a bicyclic monoterpene ketone. Camphor acts as a topical analgesic and antipruritic agent by stimulating nerve endings in the skin to produce a cooling sensation and counterirritant effect. It is used in over-the-counter products for relief of pain (such as muscle aches), itching, and cough suppression when applied topically or inhaled at low concentrations. Camphor also has mild antiseptic properties. The mechanism of action primarily involves stimulation of sensory nerves and local vasodilation; it may also have weak antimicrobial effects. Oral ingestion or use on broken skin can cause severe toxicity[1][2][3][5]. Camphor leaf oil is not an FDA-approved pharmaceutical drug but is present in some nonprescription products at regulated concentrations[4].

Brand names
Fast Freeze
Other names
camphor essential oilwhite camphor oilCinnamomum camphora oilcamphorated oilcamphor hydrosol
02

Targets

TRPA1 (Transient receptor potential cation channel subfamily A member 1)Microbial lipid membraneTRPV1 (Transient receptor potential cation channel subfamily V member 1)TRPV3 (Transient receptor potential vanilloid subtype 3)

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