Drug intelligence / Profile preview

camrelizumab + gemcitabine + cisplatin

Development stage
Unknown
Lead developer
Hengrui Pharmaceutical
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous
01

Overview

Camrelizumab + gemcitabine + cisplatin is a combination therapy consisting of an anti-PD-1 antibody (camrelizumab) with two chemotherapy agents (gemcitabine and cisplatin). This combination has shown significant efficacy in the treatment of recurrent or metastatic nasopharyngeal carcinoma. The CAPTAIN-1st phase 3 trial demonstrated that adding camrelizumab to gemcitabine and cisplatin significantly improved progression-free survival compared to gemcitabine and cisplatin alone, with a manageable safety profile. The combination works through immune checkpoint inhibition (camrelizumab) alongside the cytotoxic effects of traditional chemotherapy (gemcitabine and cisplatin).

Other names
camrelizumab plus gemcitabine and cisplatincamrelizumab plus GP
02

Targets

DNA polymerase familyDNAPDCD1 (Programmed cell death protein 1 receptor)

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