Drug intelligence / Profile preview

camylofin + paracetamol

Development stage
Unknown
Lead developer
AGP
Modality
Small Molecules
Administration
Oral
01

Overview

Anafortan Plus is a fixed-dose combination medication developed and marketed by AGP Pharma, primarily used for the management of spasmodic pain. It consists of camylofin dihydrochloride and paracetamol (acetaminophen). Camylofin is a dual-action antispasmodic that functions as a muscarinic acetylcholine receptor antagonist and a phosphodiesterase-4 (PDE4) inhibitor, leading to the relaxation of smooth muscles in the gastrointestinal, biliary, and genitourinary tracts. Paracetamol serves as an analgesic and antipyretic by inhibiting prostaglandin synthesis, primarily within the central nervous system. The Plus variant is distinguished by a higher dose of camylofin (50 mg) compared to the standard Anafortan formulation (25 mg), providing enhanced relief for acute conditions such as renal colic, biliary colic, and severe spasmodic dysmenorrhea.

Brand names
Anafortan Plus
Other names
camylofin + acetaminophen
02

Targets

COX-3 (Mitochondrially encoded cytochrome c oxidase subunit 3)MPO (Myeloperoxidase)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)CHRM3 (M3)PTGS1 (Prostaglandin-endoperoxide synthase 1)PDE4 (Phosphodiesterase 4A1)

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