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CAMYO-06
- Development stage
- Preclinical
- Lead developer
- myNEO Therapeutics
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Vaccines & Immunotherapeutics
- Administration
- Oral
01
Overview
CAMYO-06 is a preclinical mRNA-based cancer vaccine developed by myNEO Therapeutics for the treatment of microsatellite stable colorectal cancer (MSS-CRC). The vaccine leverages myNEO's proprietary 'camyotopes' technology, which identifies tumor-specific peptides (camyopeptides) derived from the 'dark genome' (amyoRNAs). These peptides are presented by MHC-I complexes on the surface of tumor cells. By delivering mRNA encoding these camyotopes, the vaccine is designed to stimulate a robust and specific CD8+ T-cell immune response against the cancer cells, addressing a significant unmet need in MSS-CRC patients who typically show poor response to standard checkpoint inhibitors.
- Other names
- CAMYO-06-myNEO Therapeutics-camyotopes-mRNA-MSS-CRCCAMYO06-myNEO Therapeutics-camyotopes-mRNA-MSS-CRCCAMYO 06-myNEO Therapeutics-camyotopes-mRNA-MSS-CRC
02
Targets
pMHC-I (Peptide–MHC class I complex)
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