Canalevia-CA2

**Canalevia-CA2** is a canine-specific veterinary formulation of **crofelemer**, a plant-derived antidiarrheal botanical drug being developed by Jaguar Animal Health for dogs. It has been described by the sponsor as an **oral solution** formulation intended for **exercise-induced diarrhea in dogs**, a follow-on canine diarrhea indication distinct from the conditionally approved tablet product Canalevia-CA1 for chemotherapy-induced diarrhea. Crofelemer acts locally in the gastrointestinal tract and is believed to reduce intestinal chloride and water secretion by inhibiting apical chloride channels, particularly **cystic fibrosis transmembrane conductance regulator** and **calcium-activated chloride channels**, thereby decreasing secretory diarrhea. Based on publicly available evidence, Canalevia-CA2 appears to have been a named development candidate and trademarked product concept rather than a fully approved marketed product as of the latest identifiable sources.

Brand names

Canalevia-CA2Canalevia-CA-2Canalevia-CA 2