Drug intelligence / Profile preview

Candiplus

Development stage
Phase 3
Lead developer
ProFem
Modality
Small Molecules
Administration
Topical, Vaginal
01

Overview

Candiplus (also referred to as Prof-001) is a novel therapeutic developed for the treatment of frequently recurring vaginal fungal infections, particularly chronic recurrent vulvovaginal candidiasis. It is based on a new therapeutic strategy designed to achieve a sustainable cure and overcome biofilm resistance mechanisms that contribute to relapse and treatment failure. Clinical studies, including phase IIa and phase IIb/III trials conducted in Europe, have demonstrated significantly improved primary cure rates and reduced relapse rates compared to standard therapies. The drug provides rapid pain relief within 12–24 hours and shows evidence of reducing recurrence by up to 50% during follow-up periods[8]. The precise mechanism of action has not been fully disclosed but is described as novel in overcoming biofilm resistance.

Brand names
Candiplus
Other names
Prof-001Prof001Prof 001Candiplus
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)CYP51A1 (Sterol 14α-demethylase)PGHS-1 (Prostaglandin G/H Synthase 1)

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