Candistat

Candistat is a brand name for a line of azole antifungal medications, primarily encompassing formulations of **itraconazole** and **miconazole**. As a systemic treatment, the itraconazole capsule formulation is utilized for a variety of fungal infections, including blastomycosis, histoplasmosis, aspergillosis, and onychomycosis. It functions by inhibiting the fungal cytochrome P450-dependent enzyme 14α-demethylase (encoded by the CYP51A1 gene), which is critical for the biosynthesis of ergosterol. The resulting depletion of ergosterol and accumulation of methylated sterol precursors lead to the disruption of fungal cell membrane structure and function. Additionally, Candistat is marketed as a topical cream containing miconazole for the treatment of superficial fungal skin infections. The brand is primarily distributed in specific international markets, such as the Philippines, by manufacturers like Unilab.

Brand names

CandistatCandiaStat