cannabidiol + tetrahydrocannabinol

Pure Green sublingual tablets are a combination therapy containing cannabidiol (CBD) and tetrahydrocannabinol (THC) developed by Pure Green Pharmaceuticals for the management of pain associated with osteoarthritis of the knee. This small molecule formulation targets the endocannabinoid system, specifically interacting with cannabinoid receptors to modulate pain signaling and inflammatory responses. The product is designed as a water-soluble, rapidly dissolvable sublingual tablet, a route of administration intended to bypass first-pass metabolism, improve bioavailability, and enhance patient compliance. The therapy was evaluated in a Phase 2 open-label clinical trial (NCT04195269) to assess its safety and efficacy in reducing average daily pain scores, as well as its impact on quality of life, sleep, and anxiety in patients with knee osteoarthritis.

Brand names

Sativex

Other names

Pure Green sublingual tabletsPure Green CBD/THC tabletsPure Green CBD + THC sublingual tablets