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cannabidiol + cannabinol (Wroclaw Medical University)
- Development stage
- Phase 3
- Lead developer
- Wroclaw Medical University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This investigational aqueous solution is a combination of the phytocannabinoids cannabidiol (CBD) and cannabinol (CBN), developed by Wroclaw Medical University for the treatment of chronic facial pain and headaches of muscular origin. CBD and CBN are non-psychoactive or mildly psychoactive compounds derived from the Cannabis sativa plant that interact with the endocannabinoid system to modulate pain signaling and inflammatory responses. The formulation is administered orally, with dosing determined by a physician, and is currently being evaluated in a Phase 2 randomized, double-blind, placebo-controlled trial (NCT05961501) to assess its efficacy in reducing pain intensity and improving muscle function as measured by electromyography and pressure pain threshold tests.
- Other names
- CBD + CBN oral solutionCBD + CBN aqueous solution
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))CNR1 (Cannabinoid receptor 1)TRPV1 (Transient receptor potential cation channel subfamily V member 1)GPR55 (G protein-coupled receptor 55)
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