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Drug intelligence / Profile preview
cannabidiol + dexanabinol
- Development stage
- Discontinued
- Lead developer
- SOL Global Investments Corp.
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A proprietary oral combination of cannabidiol (CBD) and the synthetic cannabinoid dexanabinol (HU-211) developed for the treatment of traumatic brain injury (TBI) and concussion. The therapy was initially developed through a collaboration between Scythian Biosciences and the University of Miami Miller School of Medicine. The mechanism of action involves CBD-mediated activation of receptors that trigger cellular repair and dexanabinol-mediated NMDA receptor antagonism to prevent calcium accumulation and neuroinflammation. While pre-clinical rodent studies showed improved cognitive function post-injury, development stalled after Scythian Biosciences (rebranded as SOL Global Investments) pivoted away from biotechnology and planned to spin off the program into Impact Biosciences.
- Other names
- CBD + dexanabinolCBD + HU-211
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))CNR1 (Cannabinoid receptor 1)FAAHNMDAR (Glutamate receptor ionotropic, NMDA)PPARG (Peroxisome proliferator-activated receptor gamma)TRPV1 (Transient receptor potential cation channel subfamily V member 1)NF-κB
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