cannabidiol + massed prolonged exposure therapy

Cannabidiol (CBD) is a non-psychoactive small molecule cannabinoid being investigated as an adjunct to massed Prolonged Exposure (mPE) therapy for the treatment of post-traumatic stress disorder (PTSD). Developed in this context by The University of Texas Health Science Center at San Antonio, the treatment regimen involves a 250mg oral dose of CBD taken twice daily alongside intensive psychotherapy sessions. CBD is hypothesized to enhance the efficacy of mPE by modulating the endocannabinoid system—specifically through 5-HT1A receptor agonism and FAAH inhibition—to reduce anxiety and facilitate extinction learning, which is the process of weakening the association between trauma cues and fear responses.

Other names

CBDCannabidiol oral solution