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cannabidiol + resveratrol

Development stage: Preclinical
Lead developer: InnoCan Pharma
Modality: Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Small Molecules
Administration: Oral, Topical, Inhalation

Overview

Cannabidiol + resveratrol is a combination of the non-psychoactive cannabinoid cannabidiol (CBD) and the natural polyphenol resveratrol, investigated for their synergistic anti-inflammatory, antioxidant, and neuroprotective properties. Cannabidiol modulates the endocannabinoid system primarily as a negative allosteric modulator of CB1 and CB2 receptors, while also acting as an agonist at 5-HT1A and TRPV1 receptors. Resveratrol is a potent antioxidant and a well-characterized activator of Sirtuin 1 (SIRT1), an enzyme involved in cellular homeostasis, DNA repair, and longevity pathways. This combination is widely utilized in the nutraceutical industry for general wellness and dermatological applications. In the pharmaceutical sector, companies like Innocan Pharma are developing advanced delivery systems, such as CBD and resveratrol-loaded exosomes (CLX), to treat systemic inflammatory conditions, including lung inflammation associated with COVID-19.

Other names: CBD + Resveratrol

Targets

SIRT1 (NAD-dependent protein deacetylase sirtuin-1)CNR2 (Cannabinoid receptor type 2)TRPV1 (Transient receptor potential cation channel subfamily V member 1)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))

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