cannabis + oxycodone

Cannabis + oxycodone is a non-standardized combination of two drugs—cannabis (containing cannabinoids such as THC and CBD) and oxycodone (a semi-synthetic opioid analgesic)—used together for pain management. Oxycodone acts primarily as a mu-opioid receptor agonist, providing potent analgesia by modulating pain signaling in the central nervous system. Cannabis contains multiple active compounds, most notably delta-9-tetrahydrocannabinol (THC), which acts mainly on cannabinoid receptors CB1 and CB2, producing both psychoactive effects and modulation of pain pathways. Preclinical studies suggest that combining cannabinoids with opioids can produce synergistic antinociceptive effects, potentially allowing for lower opioid doses to achieve similar analgesia ("opioid-sparing effect"). In human studies, this combination may enhance the analgesic effect of sub-threshold doses of oxycodone without increasing cannabis's abuse liability[1][2][9]. However, clinical trials have shown mixed results; some report no significant advantage over either drug alone except for reduced opioid consumption[2], while others note increased risk of adverse events or substance misuse when both are used together[7][8]. This combination is not an approved pharmaceutical product but represents a form of polydrug use sometimes encountered in clinical or self-medication contexts.

Brand names

Bedrocan

Other names

THC + oxycodonedelta-9-tetrahydrocannabinol + oxycodone