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cannabis extract + delta-9-tetrahydrocannabinol + cannabidiol

Development stage: Preclinical
Lead developer: Deutsches Zentrum für Medizinal Cannabis
Modality: Small Molecules
Administration: Oral

Overview

Cannabis extract + THC + CBD (specifically in a 10:10 ratio) is a medicinal cannabis-derived botanical combination containing standardized amounts of the phytocannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). It is currently being investigated in a prospective observational study in Germany, sponsored by the Deutsches Zentrum für Medizinal Cannabis, for the treatment of non-motor symptoms of Parkinson's disease, such as pain, sleep disorders, depression, stress, and anxiety. The drug functions by modulating the endocannabinoid system, primarily acting as an agonist at the cannabinoid receptors CB1 and CB2. As a plant-derived extract, it is classified as a botanical product and is used in clinical settings as a medicinal cannabis preparation rather than a traditionally approved pharmaceutical product.

Other names: medicinal cannabis extractcannabis-derived combination extractCannabis extract + THC + CBD

Targets

PPARG (Peroxisome proliferator-activated receptor gamma)NaV (Voltage-gated sodium channels)TRPM8 (Transient receptor potential cation channel subfamily M member 8)TRPV1 (Transient receptor potential cation channel subfamily V member 1)GPR55 (G protein-coupled receptor 55)TRPA1 (Transient receptor potential cation channel subfamily A member 1)TRPV2 (Transient receptor potential cation channel subfamily V member 2)CYP2C9 (Cytochrome P450 family 2 subfamily C member 9)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))ENT1 (Solute carrier family 29 member 1)GLRA1/GLRA3 (Glycine receptor subunit alpha-1 (GLRA1) and Glycine receptor subunit alpha-3 (GLRA3))CNR1 (Cannabinoid receptor 1)CYP3A4 (Cytochrome P450 3A4)CYP2C19 (Cytochrome P450 2C19)

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