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CannaRiver CBD Calm
- Development stage
- Preclinical
- Lead developer
- Canna River
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Sublingual
01
Overview
CannaRiver CBD Calm is a broad-spectrum cannabinoid tincture containing a co-formulation of cannabidiol (CBD), cannabinol (CBN), and cannabigerol (CBG). Developed by Canna River (now operating under River Botanicals), this THC-free product is designed to promote relaxation, sleep quality, and emotional balance. It is being evaluated in clinical trials (such as NCT07821840, sponsored by Associação Pan-Americana Multidisciplinar de Endocanabinologia) for the treatment of generalized anxiety disorder. The tincture exerts its therapeutic effects by modulating multiple molecular targets, including cannabinoid receptors (CB1 and CB2), serotonin 5-HT1A receptors, alpha-2 adrenergic receptors, and transient receptor potential (TRP) channels.
- Brand names
- Canna River CBD + CBN + CBG Ultra Calm TinctureCanna River CBD Calm TinctureCanna River Calm TinctureCanna River Ultra Calm TinctureCannaRiver CBD Calm
- Other names
- CBD + CBN + CBG Calm Tincturecannabidiol + cannabinol + cannabigerol
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))ADRA2A (α2A)CNR1 (Cannabinoid receptor 1)PPARG (Peroxisome proliferator-activated receptor gamma)TRPM8 (Transient receptor potential cation channel subfamily M member 8)TRPV1 (Transient receptor potential cation channel subfamily V member 1)
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