Drug intelligence / Profile preview

cannflavin a + cannflavin b

Development stage
Preclinical
Lead developer
Delica
Modality
Small Molecules
01

Overview

Cannflavins A + Cannflavins B is a preclinical small molecule combination therapy being developed by Delica Therapeutics. The active ingredients are non-psychoactive prenylated flavonoids derived from *Cannabis sativa L.*, which are chemically distinct from cannabinoids like THC. The drug acts as a potent anti-inflammatory agent by inhibiting prostaglandin E2 (PGE2) synthesis and 5-lipoxygenase (5-LOX), reportedly exhibiting potency approximately 30 times greater than aspirin by weight. Delica is investigating the compound for primary indications in inflammation and neuroprotection, with additional research exploring its potential in neurodegenerative diseases, oncology, and infectious diseases.

Other names
Cannflavins A & BCFL-A + CFL-BCannflavin A + Cannflavin B
02

Targets

ALOX12 (Arachidonate 12-lipoxygenase, 12S type)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)PTGES (Microsomal prostaglandin E synthase-1)

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