Drug intelligence / Profile preview

CannQuit-O

Development stage
Preclinical
Lead developer
Incannex Healthcare
Modality
Small Molecules
Administration
Oral
01

Overview

**CannQuit-O** is an investigational oral fixed-dose small-molecule combination developed for **opioid use disorder**. Incannex acquired the CannQuit assets from APIRx Pharmaceuticals in 2022 and subsequently advanced CannQuit-O through a U.S. FDA pre-IND meeting completed on May 7, 2024. The product is a water-soluble chewable tablet designed with FDA-approved polymers to provide rapid and sustained release of cannabidiol and undisclosed opioid agonist and antagonist active ingredients. Its therapeutic rationale is to combine cannabinoid pharmacology with modulation of opioid signaling in a formulation intended to improve oral bioavailability and support treatment of opioid use disorder. ([sec.gov](https://www.sec.gov/Archives/edgar/data/1873875/000121390024040253/ea020538401ex99-1_incannex.htm))

Brand names
CannQuit-O
Other names
CheWell
02

Targets

CNR1 (Cannabinoid receptor 1)MOR (Mu opioid receptor)

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