Drug intelligence / Profile preview

Cantabell

Development stage
Phase 4
Lead developer
Chong Kun Dang Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

**Cantabell** is an oral fixed-dose antihypertensive combination marketed by Chong Kun Dang that contains candesartan cilexetil and amlodipine. Candesartan cilexetil is a prodrug of candesartan, a selective angiotensin II type 1 receptor antagonist, while amlodipine is a dihydropyridine L-type calcium-channel blocker. The complementary mechanisms reduce vascular tone and lower blood pressure. Cantabell is indicated for essential hypertension inadequately controlled with candesartan cilexetil or amlodipine monotherapy. A completed Phase 4 trial evaluated Cantabell against candesartan cilexetil + hydrochlorothiazide in patients with hypertension inadequately controlled by candesartan monotherapy. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04521023))

Brand names
Cantabell
Other names
amlodipine + candesartan cilexetilcandesartan cilexetil + amlodipine
02

Targets

AGTR1 (Angiotensin II Type-1 receptor)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)

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