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capecitabine + gemcitabine + vinorelbine

Development stage: Discontinued
Lead developer: Roche
Modality: Small Molecules
Administration: Oral, Intravenous

Overview

A combination chemotherapy regimen consisting of capecitabine, gemcitabine, and vinorelbine. This three-drug combination has been investigated for the treatment of non-small cell lung cancer (NSCLC) but showed disappointing antitumor activity with unexpected life-threatening pulmonary toxicity in clinical trials.

Targets

TUBB (Tubulin (alpha and beta subunits))DNA polymerase familyRNR (Ribonucleotide reductase)TS (Thymidylate synthase)

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