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capivasertib + sunitinib
- Development stage
- Preclinical
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Capivasertib + sunitinib is an investigational combination of two small molecule kinase inhibitors, each with distinct but potentially complementary mechanisms of action in oncology. Capivasertib is a selective inhibitor of all three isoforms of the serine/threonine kinase AKT (AKT1, AKT2, and AKT3), a key node in the PI3K/AKT signaling pathway that regulates cell proliferation and survival. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor that blocks several receptors involved in tumor angiogenesis and growth, including vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs), KIT, FLT3, CSF1R, and RET. Both drugs are approved individually for various cancers but there is no evidence from the provided sources or current literature that this specific combination has been approved or widely studied together as a fixed regimen.
- Brand names
- Truqap (capivasertib)Sutent (sunitinib)
- Other names
- capivasertib + sunitinib
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)AKT2 (Rac-beta serine/threonine-protein kinase)AKT3 (RAC-gamma serine/threonine-protein kinase)CDK2 (Cyclin-dependent kinase 2)CSF1R (Macrophage colony-stimulating factor receptor)FLT3 (Fms related receptor tyrosine kinase 3)ITK (Interleukin 2-inducible T-cell kinase)KIT (c-KIT proto-oncogene receptor tyrosine kinase)PDGFRA (Platelet-derived growth factor receptor alpha)PDGFRB (Platelet-derived growth factor receptor beta)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)
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