caprospinol

Caprospinol is a synthetic steroid derivative based on the structure of 22R-hydroxycholesterol and classified as a spirostenol. It was developed as a disease-modifying drug candidate for Alzheimer's disease. Caprospinol acts by directly binding to beta-amyloid (Aβ42) peptides, inhibiting their oligomerization and the formation of neurotoxic amyloid-derived diffusible ligands (ADDLs), thereby reducing amyloid plaque formation in the brain. Additionally, it interacts with mitochondrial respiratory chain components to protect mitochondrial function and neuronal viability. Caprospinol also functions as a sigma-1 receptor ligand but does not bind to classical steroid receptors. In preclinical studies, it demonstrated neuroprotective effects by clearing beta-amyloid plaques and restoring memory capacity in animal models of Alzheimer's disease[1][2][9].

Other names

diosgenin caproatediosgenin-3-caproatediosgenin3-caproatediosgenin 3-caproate(22R,25R)-20 alpha-spirost-5-en-3beta-yl hexanoate