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capryloyl glycine
- Development stage
- Preclinical
- Lead developer
- Krufren Pharma
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Capryloyl glycine is a small molecule lipoamino acid, specifically N-octanoylglycine, developed by Krufren Pharma for applications in cosmetics and dermatology. It functions as a skin-purifying agent by inhibiting the proliferation of microorganisms, including bacteria such as *Propionibacterium acnes* and fungi like *Malassezia furfur*, which are associated with acne and seborrheic dermatitis. Additionally, capryloyl glycine acts as a 5-alpha-reductase inhibitor, effectively reducing excessive sebum production. It also helps to restore and maintain the skin's natural acid mantle by supporting an acidic pH, thereby enhancing the skin barrier function. Krufren Pharma includes this compound in its pipeline for the treatment of various dermatological disorders.
- Other names
- N-octanoylglycineCapryloylglycineOctanoylglycine
02
Targets
ODC1 (Ornithine decarboxylase)SRD5A (Steroid 5-alpha-reductase)
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