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Drug intelligence / Profile preview
capsaicin + diclofenac + linseed oil + menthol + methyl salicylate
- Development stage
- Unknown
- Lead developer
- Blue Cross Laboratories
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Diclotal Forte Gel is a topical fixed-dose combination gel developed by Blue Cross Laboratories for the local symptomatic relief of pain and inflammation associated with musculoskeletal disorders, sprains, strains, low back pain, and arthritis. The formulation combines the nonsteroidal anti-inflammatory drug (NSAID) diclofenac (as diclofenac diethylamine) with methyl salicylate, menthol, capsaicin, and linseed oil. Diclofenac and methyl salicylate act as cyclooxygenase (COX) inhibitors to reduce prostaglandin synthesis, thereby alleviating pain and swelling. Menthol and methyl salicylate function as counterirritants to produce cooling and warming sensations that distract from deeper pain, while capsaicin acts as a transient receptor potential vanilloid 1 (TRPV1) agonist to deplete substance P and block pain signals. Linseed oil, rich in alpha-linolenic acid, provides additional anti-inflammatory properties and soothes skin irritation.
- Brand names
- Diclotal Forte Gel
- Other names
- diclofenac + capsaicin + linseed oil + menthol + methyl salicylatediclofenac diethylamine + linseed oil + menthol + methyl salicylate + capsaicindiclofenac diethylamine + linseed oil + methyl salicylate + menthol + capsaicin
02
Targets
TRPM8 (Transient receptor potential cation channel subfamily M member 8)TRPV1 (Transient receptor potential cation channel subfamily V member 1)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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