Drug intelligence / Profile preview

capsaicin + ranitidine + diclofenac

Development stage
Approved
Lead developer
Astellas Pharma
Modality
Small Molecules
Administration
Oral, Topical, Rectal, Intravenous, Intramuscular, Ophthalmic
01

Overview

This drug is a **combination of capsaicin, ranitidine, and diclofenac**. - **Capsaicin** is a topical analgesic and neuropeptide modulator, primarily used for neuropathic pain and temporary relief of muscle/joint pain. Its mechanism involves agonizing the transient receptor potential vanilloid 1 (TRPV1) receptor on sensory nerves, inducing desensitization and depletion of substance P, thereby reducing pain transmission[3]. - **Ranitidine** is a histamine H2 receptor antagonist indicated for gastric acid-related disorders such as peptic ulcers, GERD, and Zollinger-Ellison syndrome. It reduces gastric acid secretion by reversible inhibition of the histamine H2 receptor on gastric parietal cells[1]. - **Diclofenac** is a nonsteroidal anti-inflammatory drug (NSAID) indicated for treatment of pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Diclofenac non-selectively inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), enzymes needed for prostaglandin synthesis, reducing inflammation and pain[6][8]. There is no evidence that capsaicin + ranitidine + diclofenac is a widely recognized or marketed product under a unique brand or code name, but the combination would be expected to provide multimodal, symptomatic relief for inflammatory musculoskeletal pain with gastrointestinal protection.

Brand names
Diclotal-RPC
Other names
Diclofenac/Ranitidine/Capsaicin
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)TRPV1 (Transient receptor potential cation channel subfamily V member 1)HRH2 (Histamine H2 Receptor)

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