capsicum extract

Capsicum extract is a natural product derived from the fruits of chili peppers, specifically *Capsicum annuum* or *Capsicum frutescens*. The extract is characterized by its content of capsaicinoids, primarily capsaicin and dihydrocapsaicin, which serve as the active pharmacological constituents. These compounds act as potent agonists of the Transient Receptor Potential Vanilloid 1 (TRPV1) receptor, initially causing a localized sensation of heat followed by desensitization of sensory nerve endings. This mechanism underlies its use as a counterirritant and rubefacient for the relief of muscular and arthritic pain. Capsicum extract is widely utilized in topical formulations such as creams, ointments, and transdermal patches, and is also found in low concentrations in oral cough and cold preparations. Additionally, specialized extracts are being developed for metabolic and weight management applications due to their thermogenic properties.

Brand names

Capsifen

Other names

Capsicum annuum extractCapsicum frutescens extractCapsicum oleoresinChili pepper extract