capsicum oleoresin

Capsicum oleoresin is a concentrated botanical extract derived from the fruits of the genus *Capsicum*, primarily *Capsicum annuum* and *Capsicum frutescens*. It is a complex mixture containing various capsaicinoids, with capsaicin being the most abundant and pharmacologically active component. The extract functions as a potent agonist of the Transient Receptor Potential Vanilloid 1 (TRPV1) channel, a non-selective cation channel found on sensory nerve endings. Upon topical application, it initially stimulates these receptors, causing a sensation of heat and localized irritation. Prolonged or repeated application leads to the depletion of substance P, a neuropeptide involved in pain transmission, resulting in the desensitization of sensory neurons and subsequent analgesia. Capsicum oleoresin is widely utilized as a pharmaceutical-grade active ingredient (API) in topical formulations such as creams, gels, and patches for the temporary relief of minor aches and pains associated with arthritis, simple backache, strains, and sprains. Inga Pharmaceuticals is a major Indian manufacturer and supplier of this phytochemical extract for the global pharmaceutical industry.

Other names

capsicum oleoresinoleoresin capsicumcapsicum extractchili pepper extract