capsicum oleoresin + naproxen

A combination pharmaceutical product containing **capsicum oleoresin** (topical capsaicin) and **naproxen** (oral NSAID), primarily supplied as a co-packaged kit (tablet and cream) for the **temporary relief of minor aches and pains of muscles and joints** such as those associated with arthritis, tendonitis, bursitis, sprains, and strains. **Naproxen** is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing prostaglandin synthesis to provide anti-inflammatory, analgesic, and antipyretic effects. **Capsicum oleoresin** contains capsaicin, which is a selective agonist of the TRPV1 receptor in cutaneous sensory neurons; it produces local desensitization of pain fibers through prolonged receptor activation and local depletion of substance P, resulting in analgesia. This combination leverages systemic and local mechanisms to improve pain control[1][2][4][6][7].

Brand names

Naprotin

Other names

naproxen/capsaicin kitnaproxen and capsaicin kit