captopril + enalapril

Captopril and enalapril are both angiotensin-converting enzyme (ACE) inhibitors used to treat hypertension and heart failure. They work by blocking the angiotensin-converting enzyme, preventing the conversion of angiotensin I to angiotensin II, which leads to vasodilation, reduced blood pressure, and decreased workload on the heart. While they share the same mechanism of action, they have some differences in pharmacokinetics and clinical effects. Captopril was the first ACE inhibitor approved for clinical use in 1981, while enalapril is a prodrug that requires hepatic biotransformation to form enalaprilat, its active metabolite. Both drugs have been used in the treatment of renal hypertension, often in combination with other medications like furosemide and propranolol.