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CAR ICT CD123
- Development stage
- Preclinical
- Lead developer
- Instituto de Biomedicina de Sevilla
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
CAR ICT CD123 is an autologous chimeric antigen receptor (CAR) T-cell therapy targeting CD123 (interleukin-3 receptor subunit alpha), currently in development for the treatment of acute myeloid leukemia (AML). The therapy is produced using a proprietary manufacturing method known as Immunocoaching T Cells (ICT), which involves culturing whole bone marrow samples from AML patients with a CD3-CD123 bispecific antibody and a specific cocktail of cytokines and checkpoint inhibitors. This process is designed to overcome common manufacturing failures in AML by enhancing T-cell viability, expansion, and tumor-homing capabilities. The CAR construct incorporates both CD28 and 4-1BB costimulatory domains to optimize persistence and anti-tumor activity.
- Other names
- Immunocoaching T Cells CD123CAR-T CD123 ICT
02
Targets
IL3RA (Interleukin 3 Receptor)
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