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CAR-M-C-MET

Development stage: Phase 1
Lead developer: Peking Union Medical College Hospital
Modality: CAR-Macrophages → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Intravenous

Overview

CAR-M-C-MET is an experimental chimeric antigen receptor macrophage (CAR-M) therapy developed by Peking Union Medical College Hospital. This cellular immunotherapy involves macrophages genetically modified to express a CAR targeting the c-MET (hepatocyte growth factor receptor) protein, which is frequently overexpressed in pancreatic ductal adenocarcinoma. CAR-M cells are designed to overcome the physical and immunological barriers of solid tumors by actively infiltrating the tumor stroma, phagocytosing c-MET-expressing cancer cells, and stimulating a broader adaptive immune response through antigen presentation. It is currently being investigated in a Phase 1 investigator-initiated trial for patients with advanced-stage pancreatic cancer who have failed standard chemotherapy.

Other names: Chimeric Antigen Receptor Macrophages targeting C-MET

Targets

MET (Mesenchymal-epithelial transition factor receptor)

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