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CAR-MOG Tregs

Development stage: Preclinical
Lead developer: Sangamo Therapeutics
Modality: CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Intravenous

Overview

CAR-MOG Tregs are an experimental cell therapy consisting of regulatory T cells (Tregs) engineered to express a chimeric antigen receptor (CAR) specific for myelin oligodendrocyte glycoprotein (MOG). Developed as a potential treatment for multiple sclerosis (MS), these cells are designed to localize to the central nervous system where MOG is expressed. Upon engagement with MOG, the CAR-Tregs activate and exert localized immunosuppression through the secretion of anti-inflammatory cytokines like IL-10 and TGF-beta, thereby reducing neuroinflammation without the systemic side effects of traditional immunosuppressants. The CAR construct is typically derived from the 8.18 C5 monoclonal antibody clone.

Other names: MOG-CAR Tregsanti-MOG CAR-Tregs

Targets

MOG (Myelin oligodendrocyte glycoprotein)

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