CAR-REP-M1 cells

**CAR-REP-M1 cells** are engineered chimeric antigen receptor (CAR) macrophages designed for adoptive cell therapy in solid tumors. These cells express a CAR targeting a tumor-associated antigen, enabling phagocytosis of cancer cells, remodeling of the immunosuppressive tumor microenvironment (TME), recruitment and activation of endogenous T cells and NK cells, antigen presentation, and induction of antigen spreading for long-term anti-tumor immunity. Developed as a novel approach to overcome limitations of CAR-T therapies in solid tumors, they demonstrate synergy with PD-1/PD-L1 checkpoint inhibitors, enhancing T cell infiltration and tumor control in preclinical immunocompetent models. No specific developer or clinical trial data for this exact designation is identified in available sources; it represents a research-stage CAR-macrophage (CAR-M) construct.