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CAR-T LeY
- Development stage
- Preclinical
- Lead developer
- Shanghai YaKe Biotechnology
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies
- Administration
- Intravenous
01
Overview
CAR-T LeY is an investigational chimeric antigen receptor (CAR) T-cell therapy being developed by YaKe Biotechnology for the treatment of acute myeloid leukemia (AML). The therapy involves engineering a patient's T cells to express a CAR that specifically recognizes the Lewis Y (LeY) antigen, a carbohydrate antigen frequently overexpressed on the surface of various tumor cells, including those in AML. Upon reinfusion into the patient, these engineered CAR-T cells bind to LeY-expressing leukemic cells, leading to T-cell activation, expansion, and targeted cytotoxicity against the tumor. As of the latest pipeline information, the product is in the preclinical evaluation stage.
- Other names
- Lewis Y antigen CAR-T cell therapy
02
Targets
LeY (Lewis Y antigen)
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