CAR.MUC1 T cells

CAR.MUC1 T cells are genetically engineered autologous or allogeneic T cells modified to express a chimeric antigen receptor (CAR) targeting Mucin 1 (MUC1), a transmembrane glycoprotein that is aberrantly glycosylated and overexpressed in various solid tumors, including breast, prostate, pancreatic, and non-small cell lung cancers. The CAR construct typically incorporates a single-chain variable fragment (scFv) derived from a MUC1-specific monoclonal antibody (such as HMFG2 or 5E5) fused to intracellular signaling domains, commonly including CD3ζ and costimulatory domains like 4-1BB (CD137) or CD28. To overcome the immunosuppressive tumor microenvironment and enhance persistence, researchers have explored co-expressing inverted cytokine receptors (e.g., 4/7ICR) or chimeric costimulatory receptors (e.g., TR2.4-1BB) to target myeloid-derived suppressor cells (MDSCs) and promote T-cell expansion at the tumor site.

Other names

CAR-MUC1 T cellsCAR-MUC-1 T cellsCAR-MUC 1 T cellsMUC1 CAR-T cellsMUC-1 CAR-T cellsMUC 1 CAR-T cellsMUC1-directed CAR-T cellsMUC-1-directed CAR-T cellsMUC 1-directed CAR-T cellsMUC1-specific CAR T cellsMUC-1-specific CAR T cellsMUC 1-specific CAR T cellsMUC1-targeting CAR T cellsMUC-1-targeting CAR T cellsMUC 1-targeting CAR T cells