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CAR1922T2 T cells
- Development stage
- Phase 1
- Lead developer
- Tongji Hospital
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
**CAR1922T2 T cells** are an investigational, dual-targeted chimeric antigen receptor T-cell therapy designed to recognize **CD19** and **CD22**, two B-cell lineage antigens commonly expressed in B-cell acute lymphoblastic leukemia and B-cell non-Hodgkin lymphoma. The engineered CAR-T product incorporates a Toll-like receptor 2-containing signaling design intended to augment T-cell activation and antitumor activity. It is being evaluated by Tongji Hospital as a single intravenous infusion following lymphodepleting therapy for relapsed or refractory B-cell acute lymphoblastic leukemia and non-Hodgkin lymphoma.
- Other names
- TLR2-containing CD19/CD22-targeted CAR-T cells
02
Targets
CD19 (B lymphocyte antigen CD19)CD22 (Cluster of Differentiation 22)
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