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CARAMEL IST

Development stage: Unknown
Lead developer: Century Therapeutics
Modality: iPSCs → Pluripotent Stem Cells → Stem Cell Therapies → Cell Therapies
Administration: Intravenous

Overview

CARAMEL IST is an investigator-sponsored clinical trial program developed by Century Therapeutics in collaboration with Friedrich-Alexander University Erlangen-Nürnberg. The program utilizes allogeneic iT cell therapy derived from induced pluripotent stem cells (iPSCs) engineered with Century's proprietary Allo-Evasion™ 5.0 technology. This platform is designed to create off-the-shelf cell therapies that can evade the host immune system, potentially allowing for repeat dosing and broader patient access. The CARAMEL IST is being evaluated for the treatment of B-cell-mediated autoimmune diseases, solid tumors, and other indications, representing a versatile approach to cell-based immunotherapy.

Other names: Century Therapeutics investigator-sponsored trial

Targets

CD19 (B lymphocyte antigen CD19)

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