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carbasalate calcium
- Development stage
- Phase 4
- Lead developer
- University Medical Center Utrecht
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Carbasalate calcium is a water-soluble complex of calcium acetylsalicylate and urea that provides acetylsalicylic acid activity. It is an oral salicylate antiplatelet agent: acetylsalicylic acid irreversibly acetylates platelet cyclooxygenase-1, suppressing thromboxane A2 production and thereby reducing platelet aggregation for prevention of arterial thrombotic events. Higher-dose products may also be used for analgesic, antipyretic, and anti-inflammatory effects. Dutch products include Ascal formulations, including 100 mg antiplatelet formulations equivalent to approximately 78.6 mg acetylsalicylic acid. ([pubchem.ncbi.nlm.nih.gov](https://pubchem.ncbi.nlm.nih.gov/compound/Carbaspirin-calcium))
- Brand names
- AscalAscal CardioAscal Cardio-Neuro
- Other names
- carbaspirin calciumcalcium carbasalatecarbosalate calciumcalcium acetylsalicylic carbamidatecalcium acetylsalicylate complex with urea
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)
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