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carboplatin + cisplatin + gemcitabine + pemetrexed
- Development stage
- Unknown
- Lead developer
- Johnson Matthey
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
This is not a standard four-drug combination used in clinical practice. These are individual chemotherapy drugs that are typically used in various two-drug combinations for treating non-small cell lung cancer (NSCLC) and mesothelioma. Common combinations include pemetrexed + cisplatin, gemcitabine + cisplatin, pemetrexed + carboplatin, and gemcitabine + carboplatin.
02
Targets
RNR (Ribonucleotide reductase)GART (GAR transformylase)DHFR (Dihydrofolate reductase)DNATS (Thymidylate synthase)
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