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carboplatin + cyclophosphamide + epirubicin + nab-paclitaxel + paclitaxel
- Development stage
- Unknown
- Lead developer
- Johnson Matthey
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
A combination chemotherapy regimen consisting of carboplatin, cyclophosphamide, epirubicin, nab-paclitaxel, and paclitaxel. This combination is primarily used in neoadjuvant settings for triple-negative breast cancer (TNBC). The regimen typically involves sequential administration, such as nab-paclitaxel followed by dose-dense epirubicin/cyclophosphamide (EC), or other variations of these agents. Nab-paclitaxel is a solvent-free formulation of paclitaxel with an improved safety profile. Epirubicin is an anthracycline considered equivalent to doxorubicin in breast cancer treatment.
02
Targets
TOP2A (DNA topoisomerase II)TUBB (Tubulin (alpha and beta subunits))DNA
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